Tissue-Specific and Developmentally Regulated Transcription of the Insulin-Like Growth Factor 2 Gene
- 1 August 1987
- journal article
- research article
- Published by Mary Ann Liebert Inc in DNA
- Vol. 6 (4), 283-295
- https://doi.org/10.1089/dna.1987.6.283
Abstract
Transcription of the rat and human IGF-2 gene loci is unusually complex. The pattern of expression of these genes varies both between tissues and within a given tissue during different stages of development. Alternative splicing or possibly transcriptional initiation events generate variant IGF-2 mRNAs that contain different 5′-untranslated leader sequences. These leader exon sequences are shared with non-IGF-2 mRNAs. Certain noncoding IGF-2 gene sequence elements are transcribed extensively and are found in multiple copies elsewhere in the human genome. Furthermore, IGF-2 mRNA levels are particularly high in a variety of human malignancies.Keywords
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