The Mechanism of γ-Secretase
Open Access
- 1 August 2003
- journal article
- Published by Elsevier BV
- Vol. 278 (31), 28968-28975
- https://doi.org/10.1074/jbc.m300905200
Abstract
No abstract availableKeywords
This publication has 37 references indexed in Scilit:
- Aβ toxicity in Alzheimer’s disease: globular oligomers (ADDLs) as new vaccine and drug targetsNeurochemistry International, 2002
- γ-Secretase: never more enigmaticTrends in Neurosciences, 2001
- Biochemical Characterization of the γ-Secretase Activity That Produces β-Amyloid PeptidesBiochemistry, 2001
- A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein PrecursorPublished by Elsevier BV ,2001
- Structure of the Protease Domain of Memapsin 2 (β-Secretase) Complexed with InhibitorScience, 2000
- Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor proteinProceedings of the National Academy of Sciences, 2000
- Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activityNature, 1999
- β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACEScience, 1999
- γ-Secretase, Evidence for Multiple Proteolytic Activities and Influence of Membrane Positioning of Substrate on Generation of Amyloid β Peptides of Varying LengthJournal of Biological Chemistry, 1999
- Peptidomimetic Probes and Molecular Modeling Suggest That Alzheimer's γ-Secretase Is an Intramembrane-Cleaving Aspartyl ProteaseBiochemistry, 1999