Giant organelles containing tubules in Chediak-Higashi lymphocytes.
- 1 November 1972
- journal article
- Vol. 69 (2), 225-38
Abstract
A giant inclusion filled with structures resembling microtubules was observed in the cytoplasm of a small percentage of circulating lymphocytes from 4 children with the Chediak-Higashi syndrome (CHS). The organelles were similar in many respects to tubule-containing inclusions described previously in normal and abnormal lymphocytes. Tubule-filled organelles appear to develop by cytoplasmic sequestration, and their massive size in CHS cells may result from fusion of small organelles to form a single giant inclusion. Acid phosphatase was found only in giant tubular inclusions which had fused with lysosomal granules. The basis for the existence of these organelles in normal and abnormal lymphocytes remains obscure.This publication has 23 references indexed in Scilit:
- Chronic Lymphocytosis with Lymphocyte InclusionsAnnals of Internal Medicine, 1972
- Photosensitive CheilitisAnnals of Internal Medicine, 1971
- Intraendothelial Inclusions in Kidneys of Patients with Systemic Lupus ErythematosusAnnals of Internal Medicine, 1971
- MICROTUBULES OF SYSTEMIC LUPUS ERYTHEMATOSUSThe Lancet, 1971
- Chediak-Higashi disease. Morphologic studies of a patient and her family.1969
- Neue Organelle im peripheren Lymphozyten?*Deutsche Medizinische Wochenschrift (1946), 1968
- The Circulating Lymphocyte—Its Role in Infectious MononucleosisAnnals of Internal Medicine, 1968
- Electron-Microscopical Study of Bone Marrow Cells in a Case of Chediak-Higashi-Steinbrinck SyndromeBritish Journal of Haematology, 1968
- A New Type of Inclusion Bodies in LymphocytesScandinavian Journal of Haematology, 1968
- ORIGIN OF GRANULES IN POLYMORPHONUCLEAR LEUKOCYTESThe Journal of cell biology, 1966