Impulsive Aggression in Personality Disorder Correlates With Tritiated Paroxetine Binding in the Platelet
- 1 June 1996
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 53 (6), 531-6
- https://doi.org/10.1001/archpsyc.1996.01830060075010
Abstract
To examine the relationship between binding parameters of the platelet central serotonergic (5-HT) transporter and measures of aggression and impulsivity in adult human subjects. Maximal number of platelet tritiated paroxetine binding sites (Bmax) and dissociation constant (Kd) values were measured in patients with personality disorder (n = 24) and healthy volunteers (n = 12). Measures of aggression and impulsivity included the total score and aggression subscale of the Life History of Aggression, the Motor Aggression factor and the assault subscale of the Buss-Durkee Hostility Inventory, and the total score and motor impulsivity subscale of the Barratt Impulsiveness Scale. The Bmax, but not Kd, values of platelet tritiated paroxetine binding was inversely correlated with the Life History of Aggression total score and aggression score and with the Buss-Durkee Hostility Inventory assault score in patients with personality disorder but not in healthy volunteer subjects. This relationship was independent of influences of factors related to depression, global function, or history of alcoholism or drug abuse. Reduced numbers of platelet 5-HT transporter sites may covary with life history of aggressive behavior in patients with personality disorder. This may represent another abnormality in 5-HT function in individuals with personality disorder and aggressive behavior.Keywords
This publication has 28 references indexed in Scilit:
- Test-retest reliability of team consensus best-estimate diagnoses of axis I and II disorders in a family studyAmerican Journal of Psychiatry, 1994
- CSF Biochemistries, Glucose Metabolism, and Diurnal Activity Rhythms in Alcoholic, Violent Offenders, Fire Setters, and Healthy VolunteersArchives of General Psychiatry, 1994
- Low Versus High Prolactin Responders to Fenfluramine Challenge: Marker of Behavioral Differences in Adult Male Cynomolgus MacaquesNeuropsychopharmacology, 1993
- Primary Structure of the Human Platelet Serotonin Uptake Site: Identity with the Brain Serotonin TransporterJournal of Neurochemistry, 1993
- Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization.Proceedings of the National Academy of Sciences, 1993
- Cerebrospinal Fluid Monoamine and Adrenal Correlates of Aggression in Free-Ranging Rhesus MonkeysArchives of General Psychiatry, 1992
- Personality and Cerebrospinal Fluid Monoamine Metabolites in Alcoholics and ControlsArchives of General Psychiatry, 1991
- Serotonergic responsivity and behavioral dimensions in antisocial personality disorder with substance abuseBiological Psychiatry, 1990
- Central serotonergic function in parasuicideProgress in Neuro-Psychopharmacology and Biological Psychiatry, 1990
- Aggression, suicide, and serotonin: relationships to CSF amine metabolitesAmerican Journal of Psychiatry, 1982