In recent years there has been considerable discussion about the influence of adrenal cortical extracts on secondary shock. While some observers hold that treatment with such extracts has a distinct influence on the severity of shock produced by various means, others have expressed the opinion that adrenal cortical extracts have little or no value in either the prevention or treatment of shock. The present paper is not only concerned with the effect of adrenal extracts on animals suffering from a shock-like syndrome, but also with the effect of anterior pituitary hormones on such animals, as well as with the effect of these two principles on adrenalectomized and hypophysectomized animals in a shock-like state. Our method of producing a shock-like state (intraperitoneal injections of hypertonic glucose solution) does not claim to cause traumatic shock but does reproduce a number of symptoms which also occur in the clinical syndrome of traumatic shock.