Antigen presentation in the murine T lymphocyte proliferative response. II. Ir‐GAT‐controlled T lymphocyte responses require antigen‐presenting cells from a high responder donor
- 30 April 1978
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 8 (5), 344-347
- https://doi.org/10.1002/eji.1830080510
Abstract
The activation of T lymphocytes from poly (Glu60Ala30Tyr10)n (GAT)-primed donors by GAT-pulsed nonimmune spleen cells was shown to require identity at the I-A subregion of the major histocompatibility complex. However, GAT-primed T lymphocytes from (responder × nonresponder) F1 hybrids could only be stimulated to proliferate by GAT bound to high responder or F1 spleen cells but not by GAT bound to spleen cells from the low responder parent. The failure of spleen cells from low responder parental strains to present GAT was shown not to be due to the presence of suppressor cells in either the antigen-presenting or the responding cell populations. These results indicate that control of antigen-presenting cell-T lymphocyte interactions is one site of Ir gene expression.Keywords
This publication has 10 references indexed in Scilit:
- A Clonal Deletion Model for Ir Gene Control of the Immune ResponseScandinavian Journal of Immunology, 1978
- Antigen presentation in the murine T-lymphocyte proliferative response. I. Requirement for genetic identity at the major histocompatibility complexThe Journal of Experimental Medicine, 1977
- Histocompatibility linked immune responsiveness and restrictions imposed on sensitized lymphocytes.The Journal of Experimental Medicine, 1977
- T-lymphocyte-enriched murine peritoneal exudate cells. IV. Genetic control of cross-stimulation at the T-cell level.The Journal of Experimental Medicine, 1977
- Regulation by the H-2 gene complex of macrophage-lymphoid cell interactions in secondary antibody responses in vitro.The Journal of Experimental Medicine, 1976
- T-lymphocyte-enriched murine peritoneal exudate cells. II. Genetic control of antigen-induced T-lymphocyte proliferation.The Journal of Experimental Medicine, 1976
- T Lymphocyte-Enriched Murine Peritoneal Exudate CellsThe Journal of Immunology, 1975
- FUNCTION OF MACROPHAGES IN ANTIGEN RECOGNITION BY GUINEA PIG T LYMPHOCYTESThe Journal of Experimental Medicine, 1973
- FUNCTION OF MACROPHAGES IN ANTIGEN RECOGNITION BY GUINEA PIG T LYMPHOCYTESThe Journal of Experimental Medicine, 1973
- GENETIC CONTROL OF IMMUNE RESPONSES IN VITROThe Journal of Experimental Medicine, 1973