A novel autoantibody to a 155‐kd protein is associated with dermatomyositis

Abstract

Objective In polymyositis and dermatomyositis (DM), identified autoantibodies occur in P = 0.004). In adults with anti-p155, of several clinical features assessed only the frequency of V-sign rash was increased, but patients with this antibody were clinically distinct from those with autoantibodies to aminoacyl–transfer RNA synthetases. Conclusion A newly recognized autoantibody, anti-p155, is associated with DM and cancer-associated DM, and is one of the most common autoantibodies in this condition, occurring as frequently in children as in adults. The clinical features and immunogenetics associated with anti-p155 differ from those associated with antisynthetases.