A COMPARISON OF THE EFFECTS OF PROXIMAL AND DISTAL TUBULAR DAMAGE ON THE ACTION OF DESOXYCORTICOSTERONE AND ALDOSTERONE
- 1 August 1957
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry and Physiology
- Vol. 35 (8), 641-644
- https://doi.org/10.1139/o57-075
Abstract
The proximal tubules of the left kidney in dogs were damaged by the injection of 0.5% racemic sodium tartrate into the left renal artery. In other experiments the distal tubules were damaged by the injection of 0.05% mercuric chloride up the left ureter. In animals with proximal tubular damage, intravenous infusions of desoxycorticosterone or aldosterone which produced a significant drop in sodium excretion from the normal kidney had no effect on the amount of sodium excreted by the damaged kidney. In animals with distal tubular damage the effect of these hormones on the damaged kidney was as great as on the normal kidney.Keywords
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