Asymmetric Nickel-Catalyzed Hydrocyanation of Vinylarenes by Applying Homochiral Xantphos Ligands
- 17 April 2001
- journal article
- research article
- Published by Wiley in Chemistry – A European Journal
- Vol. 7 (8), 1614-1618
- https://doi.org/10.1002/1521-3765(20010417)7:8<1614::aid-chem16140>3.0.co;2-e
Abstract
New homochiral xantphos-type diphosphonite ligands with binaphthoxy substituents have been prepared and characterized by NMR spectroscopy. These ligands have been applied in the nickel-catalyzed hydrocyanation of styrene and other vinylarenes. Enantioselectivities up to 63 % ee have been obtained by using 4-isobutylstyrene as a substrate. Addition of an excess of ligand strongly inhibits the hydrocyanation reaction since the bis-chelate nickel complexes formed are highly stable and catalytically inactive.Keywords
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