LiClO4-Catalysed C-Alkylation of Pyrrole and Indoles with Aziridines and Epoxides
- 1 January 2003
- journal article
- research article
- Published by SAGE Publications in Journal of Chemical Research
- Vol. 2003 (2), 78-81
- https://doi.org/10.3184/030823403103173020
Abstract
Aryl- N-tosylaziridines and epoxides smoothly undergo ring-opening with pyrrole and indoles in the presence of 5M lithium perchlorate in diethyl ether (LPDE) at ambient temperature to afford the corresponding 2- and 3-alkylated pyrroles and 3-alkylated indoles in high yields with high selectivity. LiOTf is also found to be an effective catalyst for this transformation.Keywords
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