Studies on Synthetic Sweetening Agents. VII. Absorption and Excretion of Sodium cyclamate. (2)

Abstract

The absorption of CHS-Na, saccharin, or dulcin from the stomach and the small intestine of the anesthetized rat was measured. CHS-Na was very poorly absorbed, while dulcin showed the greatest absorption rate. The absorpton of CHS-Na was considerably reduced in rat and rabbit anesthetized with pentobarbital . The same results were obtained in the absorption of tolazoline, but were not in that of salicylamide. These results suggest that the decreasing in the absorption of CHS-Na or tolazoline in situ depends mainly upon the anesthetic effect of pentobarbital. And the absorption of CHS-Na was measured in the presence of other compounds. The samll intestinal absorption of CHS-Na was measured in the presence of other compounds. The small intestinal absorption of CHS-Na was accelerated by the addition of caffeine or citric acid to it.