Neuroleptic-Induced "Anhedonia" in Rats: Pimozide Blocks Reward Quality of Food
- 21 July 1978
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 201 (4352), 262-264
- https://doi.org/10.1126/science.566469
Abstract
The dopamine receptor blocker pimozide attenuated lever-pressing and running for food reward in hungry rats. In each case the characteristic behavior of pimozide-treated rats was the same as that of undrugged rats when reward was simply withheld. Drug-induced performance difficulties were ruled out by the presence of periods of normal responding in drug-treated animals. Pimozide appears to selectively blunt the rewarding impact of food and other hedonic stimuli.This publication has 13 references indexed in Scilit:
- Haloperidol: Effect of Long-Term Treatment on Rat Striatal Dopamine Synthesis and TurnoverScience, 1977
- Blockade of intracranial self-stimulation by antipsychotic drugs: Failure to correlate with central alpha-noradrenergic blockadePsychopharmacology, 1977
- Potentiation by α‐Methyltyrosine of the Suppression of Food‐Reinforced Lever‐Pressing Behaviour Induced by Antipsychotic DrugsActa Pharmacologica et Toxicologica, 1977
- Pimozide-induced extinction of intracranial self-stimulation: response patterns rule out motor or performance deficitsBrain Research, 1976
- Attenuation of intravenous amphetamine reinforcement by central dopamine blockade in ratsPsychopharmacology, 1976
- Decreased intracranial self-stimulation after neuroleptics or 6-hydroxydopamine: Evidence for mediation by motor deficits rather than by reduced rewardPsychopharmacology, 1976
- Antipsychotic Drugs: Direct Correlation Between Clinical Potency and Presynaptic Action on Dopamine NeuronsScience, 1975
- Dopamine Receptors in the BrainScience, 1975
- Increased Lever Pressing for Amphetamine After Pimozide in Rats: Implications for a Dopamine Theory of RewardScience, 1975
- Possible Etiology of Schizophrenia: Progressive Damage to the Noradrenergic Reward System by 6-HydroxydopamineScience, 1971