The incorporation of isotopic carbon (14C) into the cerebral glycogen of rabbits

Abstract

The incorporation of C14 into the brain glycogen of conscious rabbits with labelled glucose, bicarbonate and glutamate as precursors has been studied. Substantial incorporation from all these precursors was demonstrated after an interval of 5 hr. from their injection. With [C14] glucose maximal incorporation occurred at about 8 hr. from the time of injection. Hydrocortisone led to increased incorporation of C14 from labelled glucose. Some comparisons between the turnover of brain glycogen and that of skeletal and cardiac muscle are reported.