Birth Defects with Ewing's Sarcoma

Abstract

To the Editor: The finding of chromosomal translocations in Ewing's sarcoma cell lines^{1 2 3} invites comparison with other tumors of the young associated with chromosomal deletions — in particular retinoblastoma with 13q- and Wilm's tumor with 11p. On occasion, each deleted chromosome has been seen as a constitutional defect not confined to the tumor cells, in familial aggregations owing to inheritance of a translocated chromosome, and in association with specific birth defects.⁴ Although the putative translocation of Ewing's sarcoma, t(11;22), has not been reported as a constitutional defect, and just two pairs of siblings with Ewing's sarcoma have been noted,⁵ we . . .