New orally effective chromone derivatives for the treatment of asthma
- 1 October 1977
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 7 (4), 443-445
- https://doi.org/10.1007/bf01966850
Abstract
Two new chromone derivatives have been identified which possess oral anti-allergic activity in the rat PCA model of immediate hypersensitivity. They may have a wider spectrum of anti-allergic activity than disodium cromoglycate (SCG) since they are effective in in vitro tests involving sensitized basophils, in which SCG is inactive. Both compounds, when given orally, provide relief from experimental and clinical asthma in man.Keywords
This publication has 11 references indexed in Scilit:
- The effect of predosage with disodium cromoglycate (DSCG) on the dose-related inhibition of rat passive cutaneous anaphylaxis by DSCGLife Sciences, 1975
- DOXANTRAZOLE, AN ANTIALLERGIC AGENT ORALLY EFFECTIVE IN MANThe Lancet, 1975
- Inhibition of Experimental Asthma in Man by a New Drug (AH 7725) Active when Given by MouthBMJ, 1974
- Inhibition of immediate hypersensitivity reactions by disodium cromoglycate.1973
- Inhibition of Allergic Reactions by Cromoglycate and by AH 7079 in Patients with Allergic Airway DiseaseInternational Archives of Allergy and Immunology, 1973
- Degranulation of human basophil leukocytes by anti-gamma E antibody.1971
- Degranulation of Human Basophil Leukocytes by Anti-γE AntibodyThe Journal of Immunology, 1971
- Disodium cromoglycate (Intal).1970
- Passive cutaneous anaphylaxis in the rat, induced with two homologous reagin-like antibodies and its specific inhibition with disodium cromoglycate.1969
- Histamine release from human leukocytes by anti-gamma E antibodies.1969