Leucine-Rich Repeat Kinase 2 Mutations and Parkinson's Disease: Three Questions
Open Access
- 1 January 2009
- journal article
- review article
- Published by Taylor & Francis in ASN Neuro
- Vol. 1 (1), AN20090007
- https://doi.org/10.1042/an20090007
Abstract
Mutations in the gene encoding LRRK2 (leucine-rich repeat kinase 2) were first identified in 2004 and have since been shown to be the single most common cause o...Keywords
This publication has 98 references indexed in Scilit:
- Haplotype analysis of Lrrk2 R1441H carriers with parkinsonismParkinsonism & Related Disorders, 2009
- Familial parkinsonism: Study of original Sagamihara PARK8 (I2020T) kindred with variable clinicopathologic outcomesParkinsonism & Related Disorders, 2009
- Identification of compounds that inhibit the kinase activity of leucine-rich repeat kinase 2Biochemical and Biophysical Research Communications, 2009
- Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathwayNeurobiology of Disease, 2008
- The Roc domain of leucine‐rich repeat kinase 2 is sufficient for interaction with microtubulesJournal of Neuroscience Research, 2008
- Identification of potential protein interactors of Lrrk2Parkinsonism & Related Disorders, 2007
- The Parkinson’s disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase thatstimulates kinase activityExperimental Cell Research, 2007
- The R1441C mutation of LRRK2 disrupts GTP hydrolysisBiochemical and Biophysical Research Communications, 2007
- α-synuclein locus duplication as a cause of familial Parkinson's diseaseThe Lancet, 2004
- The new mutation, E46K, of α‐synuclein causes parkinson and Lewy body dementiaAnnals of Neurology, 2003