Mechanism of prostaglandin F-2 penetration from the horn of the uterus to the ovaries in pigs

Abstract

On Day 14 of the estrous cycle PG[prostaglandin]F-2.alpha. was infused into 1 anterior uterine vein (15 or 7.5 .mu.g/kg body wt) or jugular vein (15 .mu.g/kg) of pigs for 5 h. Progesterone levels were significantly decreased in the ipsilateral and contralateral utero-ovarian veins, the effect being greater on the side of infusion and with the higher dose. Infusion into the jugular vein did not cause luteolysis. The lymphatic circulation may be involved in the passage of PGF-2.alpha. from 1 uterine horn to the contralateral ovary.