Successful Therapy of Prolonged Hypotension with an Adrenergic Beta-Receptor Blocking Agent

Abstract

Two patients with prolonged hypotension requiring continuous vasopressor therapy are described. In both patients treatment with nethalide, a beta-receptor blocking agent, appeared clinically effective in allowing the withdrawal of metaraminol therapy and the maintenance of normotension. The results in these patients tend to fortify a hypothesis of peripheral adrenergic beta-receptor dominance in patients with prolonged hypotension.