Decreased generation of cyclic AMP in lymphocytes by .BETA.-adrenergic stimulation in heart failure.
- 1 January 1981
- journal article
- research article
- Published by International Heart Journal (Japanese Heart Journal) in Japanese Heart Journal
- Vol. 22 (4), 585-592
- https://doi.org/10.1536/ihj.22.585
Abstract
Peripheral blood lymphocytes from 31 normal subjects and 29 patients with heart diseases were stimulated by isoproterenol and cAMP level in lymphocytes was assayed. Simultaneously plasma norepinephrine concentration at rest was measured. In normal subjects the generation of cAMP after the stimulation decreased with age. The response of lymphocytes in patients of NYHA [New York Heart Association] classes III and IV rose significantly smaller than in the normal, age-matched control. Plasma norepinephrine concentration of patients of classes II, III and IV rose significantly above normal. In congestive heart failure, a significant correlation between plasma norepinephrine concentration and increase of lymphocyte cAMP was demonstrated. .beta.-adrenergic receptors in congestive heart failure were apparently desensitized.This publication has 6 references indexed in Scilit:
- ADRENERGIC DESENSITIZATION IN LEUKOCYTES OF NORMAL AND ASTHMATIC SUBJECTS1977
- Agonist-specific refractoriness induced by isoproterenol. Studies with mutant cells.Journal of Biological Chemistry, 1976
- The lymphocyte beta-adrenoceptor in normal subjects and patients with bronchial asthma: the effect of different forms of treatment on receptor function.Journal of Clinical Investigation, 1976
- Use of plasma norepinephrine for evaluation of sympathetic neuronal function in manLife Sciences, 1976
- Identification of beta-adrenergic receptors in human lymphocytes by (-) (3H) alprenolol binding.Journal of Clinical Investigation, 1976
- Catecholamine excretion and cardiac stores of norepinephrine in congestive heart failureAmerican Journal Of Medicine, 1965