Association of Human Papillomavirus Infection and Disease with Magnitude of Human Immunodeficiency Virus Type 1 (HIV‐1) RNA Plasma Level among Women with HIV‐1 Infection
Open Access
- 1 June 1999
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 179 (6), 1405-1409
- https://doi.org/10.1086/314754
Abstract
Ninety-three women with human immunodeficiency virus type 1 (HIV-1) infection were enrolled in a cross-sectional study to evaluate the relationship between plasma HIV-1 RNA levels and coincident cervical infection and disease caused by human papillomaviruses (HPVs). HIV-1 RNA plasma levels of >10,000 copies/mL were highly associated with the presence in cervical specimens of HPV DNA of oncogenic (high risk) virus genotypes (P = .006; relative risk, 2.57). In addition, similar HIV-1 RNA plasma levels were associated with abnormal Pap smears (P = .01; relative risk, 2.11). In this study, 81% of women with high-risk HPV cervical infection had abnormal Pap smears. Measurement of HIV-1 RNA plasma levels may help to identify a subgroup of HIV-1—infected women at increased risk for cervical HPV infection and disease.Keywords
This publication has 1 reference indexed in Scilit:
- 1993 Revised Classification System for HIV Infection and Expanded Surveillance Case Definition for AIDS Among Adolescents and AdultsPublished by American Psychological Association (APA) ,1992