Effects of ultraviolet light on the in vitro assembly of microtubules
- 13 March 1984
- journal article
- research article
- Published by American Chemical Society (ACS) in Biochemistry
- Vol. 23 (6), 1073-1080
- https://doi.org/10.1021/bi00301a006
Abstract
Exposure of microtubular protein [from calf brain] to UV light inhibits its assembly into morphologically normal microtubules. This effect appeared to result primarily from damage to the tubulin dimers. The damage consisted of a conformational change, a loss of 2 free sulfhydryl groups, a production of higher MW cross-linked species, and the formation of aggregated amorphous material on polymerization.This publication has 28 references indexed in Scilit:
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