Diffuse cutaneous leishmaniasis: A disease due to an immunological defect of the host
- 1 January 1972
- journal article
- Published by Oxford University Press (OUP) in Transactions of the Royal Society of Tropical Medicine and Hygiene
- Vol. 66 (4), 603-610
- https://doi.org/10.1016/0035-9203(72)90306-9
Abstract
Diffuse cutaneous leishmaniasis, with its characteristic diffusion of lesions, great abundance of parasites, anergy to skin tests with the specific antigen and resistance to treatment, has been described as a disease produced by a special strain of Leishmania, L. pifanoi . Our concept is that this form of leishmaniasis is due, not to a different type of parasite, but to an immunological defect of the human host, which makes him respond with these special clinical and parasitological manifestations. The basis for our belief is: (1) epidemiologically, the disease appears as isolated cases in endemic areas; (2) accidental inoculation of a laboratory technician with a strain taken from an animal with diffuse cutaneous leishmaniasis lesions produced a nodule with the clinical, pathological and parasitological characteristics of an American cutaneous lesion, with a strongly positive leishmanin reaction; (3) the coexistence, in a leishmaniasis focus, of two patients living in the same house, one of whom had diffuse cutaneous leishmaniasis and the other American cutaneous leishmaniasis; (4) clinical and pathological characteristics of an experimental inoculation in human volunteers with material obtained from diffuse cutaneous leishmaniasis lesions. This produced, in all the hosts, a typical American cutaneous leishmaniasis type of response.Keywords
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