Sulfamethoxypyridazine: Preliminary Observations on Absorption and Excretion of a New, Long-Acting Antibacterial Sulfonamide.

Abstract

In 6 normal men sulfamethoxypyridazine was well absorbed, yielding high levels of free drug and only small amounts in acetylated form in the plasma. Little if any of the drug diffuses into the blood cells. The drug is cleared slowly from the pla''sma, the acetylated form being cleared by the kidney about 11 times as fast as the free drug. Urine concentrations varied with concentrations up to about 200 mg %, between 35 and 60% being in the conjugated form. Significant levels were still present in the blood and urine 105 hours after the dose.