Hippocampal Aging and Adrenocorticoids: Quantitative Correlations
- 8 December 1978
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 202 (4372), 1098-1102
- https://doi.org/10.1126/science.715460
Abstract
Altered neural-endocrine relations have been proposed as factors in mammalian aging. In the same rats from three age groups we quantified astrocyte reactivity in hippocampus, performed radioimmunoassays for plasma adrenocorticoids, and measured adrenal weight. These variables were correlated in individual animals and generally increased with age. The findings are consistent with recent hypotheses that endocrine levels are related to brain aging, either as cause or effect.Keywords
This publication has 34 references indexed in Scilit:
- Impaired synaptic potentiation processes in the hippocampus of aged, memory-deficient ratsBrain Research, 1978
- The Regulation of Physiological Changes During Mammalian AgingThe Quarterly Review of Biology, 1976
- Induction of Estrous Cycles in Old Non-Cyclic Rats by Progesterone, ACTH, Ether Stress or L-DopaNeuroendocrinology, 1976
- Catecholamine metabolism in the brains of ageing male miceBrain Research, 1973
- Effect of Fornix Transection or Hippocampectomy on Rhythmic Pituitary-Adrenal Function in the RatNeuroendocrinology, 1973
- Chronic and Acute Dexamethasone Suppression of Stress Activation of the Adrenal Cortex in Young and Aged RatsNeuroendocrinology, 1972
- Brain RNA and Hypophysectomy; A Topographical StudyNeuroendocrinology, 1972
- Hippocampal efferents to the ipsilateral entorhinal area: An experimental study in the ratJournal of Comparative Neurology, 1971
- Telemetered Recording of Hormone Effects on Hippocampal NeuronsScience, 1971
- Ageing and the Regulation of Cell Activities during Exposure to ColdThe Journal of general physiology, 1969