In view of the interest shown salicylamide for its analgesic and antirheumatic effect, it was thought advisable to study both of these under conditions that would lead to statistical evaluation with placebo and other salicylate therapy. Ichniowski and Hueper1found that in rats salicylamide, upon oral and intraperitoneal administration, exerts a slightly quicker and deeper depressing effect than aspirin. Hart2noted that the relative analgesic potencies in animals for aspirin and salicylamide were 1 and 7 respectively. Hart also noted that, in a group of 118 patients with arthritis treated with 2 gm. of salicylamide every four to eight hours, satisfactory relief was obtained in 75% of the subjects, but 22% had some untoward reaction. Studies of clinical results with salicylamide, available principally in European literature,3favored salicylamide over aspirin. It was noted, however, that large doses of salicylamide are required and that the action of the