Effects of weight reduction on blood lipids and lipoproteins: a meta-analysis
Open Access
- 1 August 1992
- journal article
- research article
- Published by Elsevier in The American Journal of Clinical Nutrition
- Vol. 56 (2), 320-328
- https://doi.org/10.1093/ajcn/56.2.320
Abstract
Studies designed to examine effects of weight reduction by dieting on total cholesterol (TC), low-density-li-poprotein cholesterol (LDL-C), high-density-lipoprotein cholesterol (HDL-C), very-low-density-lipoprotein cholesterol (VLDL-C), and triglycerides (TGs) have reported inconsistent results. The purpose of this study was to quantify effects of weight loss by dieting on lipids and lipoproteins through the review method of meta-analysis. Results from the 70 studies analyzed indicated that weight reduction was associated with significant decreases (P ≤ 0.001) and correlations (P <≤ 0.05) for TC (r = 0.32), LDL-C (r = 0.29), VLDL-C (r = 0.38), and TG (r = 0.32). For every kilogram decrease in body weight, a 0.009-mmol/L increase (P ≤0.01) in HDL-C occurred for subjects at a stabilized, reduced weight and a 0.007-mmol/L decrease (P ≤ 0.05) for subjects actively losing weight. Our results indicate that weight reduction through dieting can be a viable approach to help normalize plasma lipids and lipoproteins in overweight individuals.Keywords
This publication has 80 references indexed in Scilit:
- A Prospective Study of Obesity and Risk of Coronary Heart Disease in WomenNew England Journal of Medicine, 1990
- Changes in Plasma Lipids and Lipoproteins in Overweight Men during Weight Loss through Dieting as Compared with ExerciseNew England Journal of Medicine, 1988
- Benefits of Aerobic Conditioning and Diet for Overweight AdultsSports Medicine, 1988
- Regulation of the production and catabolism of plasma low density lipoproteins in hypertriglyceridemic subjects. Effect of weight loss.JCI Insight, 1985
- Serum lipoprotein lipid and apolipoprotein concentrations in grossly obese patients before and after jejuno-ileal shunt operationEuropean Journal of Clinical Investigation, 1981
- Normalization of Triglycerides in Type IV Hyperlipoproteinemia Fails to Correct Low Levels of High-Density-Lipoprotein CholesterolNew England Journal of Medicine, 1980
- Comparative effects of physical training and diet in normalizing serum lipids in men with Type IV hyperlipoproteinemia.Circulation, 1977
- Changes associated with quitting cigarette smoking: The Framingham StudyAmerican Heart Journal, 1975
- THE INTRAVENOUS FAT TOLERANCE TEST IN SUBJECTS WITH MASSIVE OBESITYActa Medica Scandinavica, 1974
- Plasma Cholesterol Levels during Rapid Weight ReductionCirculation, 1951