Functional topography of the dorsomedial hypothalamus
- 1 February 2008
- journal article
- Published by American Physiological Society in American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Vol. 294 (2), R477-R486
- https://doi.org/10.1152/ajpregu.00633.2007
Abstract
The dorsomedial hypothalamus (DMH) has been proposed to play key roles in both the defense reaction to acute stress and in the thermoregulatory response to cold. We reasoned that the autonomic/respiratory motor patterns of these responses would be mediated by at least partly distinct DMH neuron populations. To test this, we made simultaneous recordings of phrenic nerve and plantar cutaneous vasoconstrictor (CVC) activity in 14 vagotomized, ventilated, urethane-anesthetized rats. Microinjections of d,l-homocysteic acid (DLH; 15 nl, 50 mM) were used to cause localized, short-lasting (Keywords
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