Incidence of pregnancy-specific beta-1-glycoprotein in sera of malignant tumor patients.

Abstract

Pregnancy-specific .beta.-1-glycoprotein (SP1) is said to be found only in sera of pregnant females. In this paper, SP1 in the sera of malignant tumor patients was investigated by Ouchterlony''s method and counterimmunoelectrophoresis (CIEP). On examination by Ouchterlony''s method, all samples were negative, but by CIEP, 34 of 90 samples (38%) showed positive reaction; 25 of 61 (41%) in males and 9 of 29 (31%) in females. There was no indication that patients with a certain type of cancer have a high incidence of SP1, but examination of SP1 in the sera of patients with cancer or suspicious cancer had some clinical significance.