Epigenetic stem cell signature in cancer
Top Cited Papers
- 31 December 2006
- journal article
- research article
- Published by Springer Nature in Nature Genetics
- Vol. 39 (2), 157-158
- https://doi.org/10.1038/ng1941
Abstract
Embryonic stem cells rely on Polycomb group proteins to reversibly repress genes required for differentiation. We report that stem cell Polycomb group targets are up to 12-fold more likely to have cancer-specific promoter DNA hypermethylation than non-targets, supporting a stem cell origin of cancer in which reversible gene repression is replaced by permanent silencing, locking the cell into a perpetual state of self-renewal and thereby predisposing to subsequent malignant transformation.Keywords
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