Dystonic reactions following neuroleptics: Time Course and proposed mechanisms
- 1 January 1976
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 47 (2), 199-201
- https://doi.org/10.1007/bf00735822
Abstract
The occurrence of acute dystonic reactions was studied relative to drug pharmacokinetic parameters following a single dose of the phenothiazine, butaperazine. Dystonias occurred more than one half-life from peak butaperazine levels, 23 to 56 h after drug administration. The authors postulate that the appearance of dystonias on falling plasma concentrations may be due to disruption of dopaminergiccholinergic balance caused by differential antidopaminergic and anticholinergic potencies of the drug.Keywords
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