Juvenile Cushing Syndrome Manifested Primarily by Growth Failure

Abstract

• An 11-year-old boy had Cushing syndrome with profound growth retardation, but without the associated clinical characteristics of the disease. Treatment with growth hormone failed to promote growth, suggesting that growth failure in the presence of excess glucocorticoids is due to peripheral tissue resistance to growth hormone rather than to impairment of growth hormone secretion. (Am J Dis Child 130:200-202, 1976)