Intramitochondrial factors controlling hepatic fatty acid oxidation at weaning in the rat
- 9 May 1988
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 232 (1), 156-158
- https://doi.org/10.1016/0014-5793(88)80407-1
Abstract
Fatty acid oxidation was studied in isolated liver mitochondria of rats during the suckling-weaning transition. The oxidation rate of oleyl-CoA and palmitoylcarnitine was reduced 2.5-fold in rats weaned on a high-carbohydrate diet compared to suckling rats, when acetyl-CoA produced by β-oxidation was directed towards ketone-body synthesis. Weaning on a high-fat diet minimized this change. Channeling of acetyl-CoA towards citrate synthesis doubled the oxidation rate of both substrates in HC-weaned rats. Thus, in addition to changes in carnitine palmitoyltransferase I activity, the β-hydroxymethylglutaryl-CoA synthase pathway is also involved in the decreased fatty acid oxidation at weaning. This was confirmed by measurement of β-hydroxymethylglutaryl-CoA synthase pathway activity.Keywords
This publication has 14 references indexed in Scilit:
- Evidence that the development of hepatic fatty acid oxidation at birth in the rat is concomitant with an increased intramitochondrial CoA concentrationEuropean Journal of Biochemistry, 1986
- Regulation of ketogenesis during the suckling–weanling transition in the rat. Studies with isolated hepatocytesBiochemical Journal, 1979
- Changes in the activities of the enzymes of hepatic fatty acid oxidation during development of the ratBiochemical Journal, 1976
- A Novel mechanism for inhibition of β‐oxidation by methylenecyclopropylacetyl‐CoA, a metabolite of hypoglycinFEBS Letters, 1975
- Hepatic mitochondrial function in ketogenic states. Diabetes, starvation, and after growth hormone administration.Journal of Clinical Investigation, 1975
- Factors involved in the control of the activity of enzymes of hepatic ketogenesis during development of the ratInternational Journal of Biochemistry, 1974
- Ketogenesis in isolated rat liver mitochondria I. Relationships with the citric acid cycle and with the mitochondrial energy stateBiochimica et Biophysica Acta (BBA) - Bioenergetics, 1972
- STUDIES ON THE BIOCHEMISTRY OF MITOCHONDRIA AND CELL MORPHOLOGY IN THE NEONATAL SWINE HEPATOCYTEThe Journal of cell biology, 1972
- Activity and intracellular distribution of enzymes of ketone-body metabolism in rat liverBiochemical Journal, 1968