Highly Enantioselective Regiodivergent and Catalytic Parallel Kinetic Resolution
- 2 March 2001
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition
- Vol. 40 (5), 930-932
- https://doi.org/10.1002/1521-3773(20010302)40:5<930::aid-anie930>3.0.co;2-7
Abstract
Chiral recognition leads to enantio- and regiodivergent reactivity: An unusual regiodivergent catalytic kinetic resolution has been accomplished for the first time in an organometallic reaction in which a C−C bond is formed. Chiral copper complexes of the non-racemic phosphoramidite ligand L* discriminate the enantiomers of semirigid vinyloxiranes (having a blocked s-cis or s-trans conformation) to give separable regioisomeric products with very high stereocontrol in a two-step process (see scheme).Keywords
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