DNA Markers for Nervous System Diseases
- 21 September 1984
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 225 (4668), 1320-1326
- https://doi.org/10.1126/science.6089346
Abstract
Recombinant DNA technology has provided a vast new source of DNA markers displaying heritable sequence variation in humans. These markers can be used in family studies to identify the chromosomal location of defective genes causing nervous system disorders. The discovery of a DNA marker linked to Huntington's disease has opened new avenues of research into this disorder and may ultimately permit cloning and characterization of the defective gene.Keywords
This publication has 22 references indexed in Scilit:
- Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresisCell, 1984
- Dominance and homozygosity in manAmerican Journal of Medical Genetics, 1983
- Recombinant DNA approach to neurogenetic disordersTrends in Neurosciences, 1982
- Altered red cell osmotic fragility in Huntington disease (HD)American Journal of Medical Genetics, 1982
- Huntington's disease: implications of associated cellular radiosensitivityClinical Genetics, 1981
- Cloning of a representative genomic library of the human X chromosome after sorting by flow cytometryNature, 1981
- Experience is the child of thoughtNew Directions for Institutional Research, 1979
- Detection of specific sequences among DNA fragments separated by gel electrophoresisJournal of Molecular Biology, 1975
- Changes in size and secondary structure of the ribosomal transcription unit during vertebrate evolutionJournal of Molecular Biology, 1975
- Mutation in Huntington's chorea.Journal of Neurology, Neurosurgery & Psychiatry, 1969