Hybridoma autoantibodies to DNA.
- 1 March 1980
- journal article
- research article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 124 (3), 1499-1502
- https://doi.org/10.4049/jimmunol.124.3.1499
Abstract
MRL/1 mice develop a severe form of systemic lupus erythematosus and spontaneously produce high levels of autoantibodies to DNA. Spleen cells from these animals were used as fusion partners to prepare hybridomas that produce autoantibodies to DNA. Since exogenous immunization was not employed, the hybridoma antibodies were derived from populations of B cells that spontaneously produced autoantibodies. Each hybridoma autoantibody had a distinctive binding specificity with S-DNA, N-DNA, or oligonucleotides.This publication has 6 references indexed in Scilit:
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