Improved Synthesis of Substituted 6,7-Dihydroxy-4-quinazolineamines: Tandutinib, Erlotinib and Gefitinib
Open Access
- 9 April 2006
- Vol. 11 (4), 286-297
- https://doi.org/10.3390/11040286
Abstract
The synthesis of three substituted 6,7-dihydroxy-4-quinazolineamines: tandutinib (1), erlotinib (2) and gefitinib (3) in improved yields is reported. The intermediates were characterized by NMR and the purities determined by HPLC.Keywords
This publication has 5 references indexed in Scilit:
- New cytotoxic and molecular-targeted therapies of head and neck tumorsCurrent Opinion in Oncology, 2004
- Epidermal growth factor receptor tyrosine kinase inhibitors in late stage clinical trialsEmerging Drugs, 2003
- Identification of Orally Active, Potent, and Selective 4-Piperazinylquinazolines as Antagonists of the Platelet-Derived Growth Factor Receptor Tyrosine Kinase FamilyJournal of Medicinal Chemistry, 2002
- CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML)Cancer Cell, 2002
- Synthesis and enzymic activity of 6-carbethoxy- and 6-ethoxy-3,7-disubstituted pyrazolo[1,5-a]pyrimidines and related derivatives as adenosine cyclic 3',5'-phosphate phosphodiesterase inhibitorsJournal of Medicinal Chemistry, 1982