EFFECT OF MITOMYCIN C ON THE GROWTH OF SOME ANIMAL VIRUSES
- 1 August 1961
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 47 (8), 1212-1217
- https://doi.org/10.1073/pnas.47.8.1212
Abstract
The growth of a ribo-nucleic acid (RNA) virus, meningo encephalomyelitis virus, and a deoxyribonucleic acid (DNA) virus, vaccinia, in mammalian cells either in the presence of, or after pretreatment with, suitable concentrations of mitomycin C was studied. The presence of biologically intact DNA is not required for normal RNA virus growth and nucleic acid synthesis. A profound inhibition of vaccinia growth is caused by mitomycin, either through pretreatment of the host cell or by its presence throughout the course of infection.Keywords
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