CRMP-2 induces axons in cultured hippocampal neurons
- 1 August 2001
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 4 (8), 781-782
- https://doi.org/10.1038/90476
Abstract
In cultured hippocampal neurons, one axon and several dendrites differentiate from a common immature process1. Here we found that CRMP-2/TOAD-64/Ulip2/DRP-2 (refs. 2, 3, 4) level was higher in growing axons of cultured hippocampal neurons, that overexpression of CRMP-2 in the cells led to the formation of supernumerary axons and that expression of truncated CRMP-2 mutants suppressed the formation of primary axon in a dominant-negative manner. Thus, CRMP-2 seems to be critical in axon induction in hippocampal neurons, thereby establishing and maintaining neuronal polarity.Keywords
This publication has 16 references indexed in Scilit:
- Differentiated neurons retain the capacity to generate axons from dendritesCurrent Biology, 2000
- Phosphorylation of Collapsin Response Mediator Protein-2 by Rho-kinaseJournal of Biological Chemistry, 2000
- Regulation of the Cytoskeleton and Cell Adhesion by the Rho Family GTPases in Mammalian CellsAnnual Review of Biochemistry, 1999
- Growth cone neuropilin-1 mediates collapsin-1/sema III facilitation of antero- and retrograde axoplasmic transportJournal of Neurobiology, 1999
- The Role of Local Actin Instability in Axon FormationScience, 1999
- Microtubules and Neuronal PolarityNeuron, 1999
- Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33Nature, 1995
- Neuronal PolarityAnnual Review of Neuroscience, 1994
- Experimentally induced alteration in the polarity of developing neuronsNature, 1987
- ‘Dendraxons’ in regenerating motoneurons in the cat: do dendrites generate new axons after central axotomy?Brain Research, 1985