Fredericamycin A a new antitumor antibiotic. I. Production, isolation and physicochemical properties.

Abstract
A new antitumor antibiotic, fredericamycin A (FCRC-A48, NSC-305263), was isolated from a strain of Streptomyces griseus (FCRC-48). Based on its unique UV-visible spectrum, IR spectrum, proton and 13C NMR spectra and mass spectra, it is judged to be a novel acid-base indicator type of compound. Its production, isolation and physicochemical properties are discussed. The isolation, UV-visible spectrum and some biological properties of 2 minor components, fredericamycin B and fredericamycin C, are also described.