A combinatorial approach to characterize the substrate specificity of proteinargininemethyltransferase 1
Open Access
- 6 July 2010
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Molecular BioSystems
- Vol. 7 (1), 48-51
- https://doi.org/10.1039/c0mb00015a
Abstract
The dysregulation of proteinarginine methyltransferases (PRMTs) is implicated in a wide variety of disease states. Here we report the design, synthesis, and screening of a combinatorial peptide library used to characterize the substrate specificity of PRMT1. The information gained from this approach was used to develop a PRMT1inhibitor with enhanced selectivity.Keywords
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