FREE IMMUNOGLOBULIN LIGHT CHAIN SYNTHESIS BY NEOPLASTIC-CELLS IN LEUKEMIC RETICULOENDOTHELIOSIS
- 1 January 1978
- journal article
- research article
- Vol. 31 (2), 244-250
Abstract
Neoplastic cell preparations from 4 patients with clinically and morphologically well-defined leukemic reticuloendotheliosis (LRE) were investigated for their capacity to synthesize immunoglobulin [Ig] in vitro. Neoplastic cells from all cases synthesized Ig of the same L chain class as expressed at their cell surface. Labeled IgM and IgD were identified in cell lysates while free L chain was the predominant labeled Ig product in the LRE culture supernatants. The capacity of LRE cells to synthesize Ig and free L chain was similar to that of neoplastic cells from patients with chronic lymphocytic leukemia, and provides further evidence for the B[bone marrow-derived]-lymphocyte origin of the neoplastic cells in LRE.This publication has 15 references indexed in Scilit:
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