Chromosomal assignments of human type I and type II cytokeratin genes to different chromosomes
- 1 January 1988
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 48 (3), 148-151
- https://doi.org/10.1159/000132612
Abstract
The chromosomal location of representative members of the type I and type II subfamilies of the cytokeratin multigene family was determined using specific cDNA probes in Southern blot hybridization with DNA from somatic cell hybrids. Our results show that the gene encoding human type II cytokeratin 4 resides on chromosome 12 and that encoding type I cytokeratin 15 is located on chromosome 17. The results indicate that cytokeratins are not concentrated in only one cluster. The possibility of the existence of separate type I and type II cytokeratin gene clusters is discussed.Keywords
This publication has 19 references indexed in Scilit:
- Clustered arrangement of keratin intermediate filament genes.Proceedings of the National Academy of Sciences, 1986
- Cytokeratin expression in simple epitheliaDifferentiation, 1986
- Three tightly linked genes encoding human type I keratins: conservation of sequence in the 5'-untranslated leader and 5'-upstream regions of coexpressed keratin genes.Molecular and Cellular Biology, 1986
- Molecular cloning and characterization of the Endo B cytokeratin expressed in preimplantation mouse embryos.Journal of Biological Chemistry, 1986
- One gene and one pseudogene for the cytokeratin endo A.Proceedings of the National Academy of Sciences, 1985
- The human desmin and vimentin genes are located on different chromosomesGene, 1985
- Heterotypic tetramer (A2D2) complexes of non-epidermal keratins isolated from cytoskeletons of rat hepatocytes and hepatoma cellsJournal of Molecular Biology, 1984
- A technique for radiolabeling DNA restriction endonuclease fragments to high specific activityAnalytical Biochemistry, 1983
- The amino acid sequence of chicken muscle desmin provides a common structural model for intermediate filament proteins.The EMBO Journal, 1982
- Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase IJournal of Molecular Biology, 1977