Macrophage–T lymphocyte relationships in man's contact allergic reactions
- 1 August 1983
- journal article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 109 (2), 183-189
- https://doi.org/10.1111/j.1365-2133.1983.tb07079.x
Abstract
Seventeen biopsies from contact allergic reaction sites in sensitized patients were studied by electron microscopy and immunocytochemistry. Very intimate appositions of macrophages to T lymphocytes were frequently observed in the dermis at 6, 8 and 12 hours after application of the allergen. Such juxtapositions were seen less frequently after 24, 48 and 72 hours. These appositions seem to indicate that macrophages play an antigen-presenting role in human contact allergic reactions, as Langerhans cells seem to do.Keywords
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