Exon/intron organization and complete nucleotide sequence of an HLA gene.
- 1 February 1982
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 79 (3), 893-897
- https://doi.org/10.1073/pnas.79.3.893
Abstract
A genomic clone was isolated and the sequence was determined containing the gene for a human class I transplantation antigen. The gene contains 7 exons. The first 5 exons code respectively for a signal peptide, for the 1st, 2nd and 3rd extracellular domains of the protein molecule and for the transmembrane region. The cytoplasmic segment is encoded by part of the 5th and the 6th and the 7th exons. The structure of the protein encoded by this unit is closely homologous with known class I transplantation antigens.Keywords
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