Interaction of Chlorpromazine with Strandin.

Abstract

The phenothiazine drugs, chlorpromazine and Stelazine (trifluoperazine), interact with heparin and chondroitin sulfate to form products of visible turbidity. This turbidity is reduced by the brain ganglioside strandin, and will reappear on the readdition of phenothiazine. Chlorpromazine reduces turbidity of the strandin-lysozyme interaction product, turbidity of which may be regenerated by subsequent addition of strandin. Equilibrium dialysis of chlorpromazine solutions and chlorpromazine-strandin solutions indicates good retention of chlorpromazine in the system containing strandia Strandin alters the UV spectrum of chlorpromazine and, more markedly, that of Stelazine. Ultracentrifuge studies indicate presence of a slow moving peak in the strandin-chlorpromazine system, which may represent the strandin-chlorpromazine interaction product.