To the Editor:— Since the report by Edith Paterson and her co-workers (Lancet1:677 [May 11] 1946) on the remarkable effect of urethane in the treatment of leukemia, the validity of this observation has been confirmed by a number of workers in this country (personal communications) and in our own clinic. The British investigators noted, however, that other forms of malignant neoplasia were not appreciably affected by the drug. In 3 of 13 cases of advanced carcinoma of the breast and in 4 of 11 other forms of malignant disease the tumor masses underwent only temporary diminution in size. We have recently observed a man aged 44 who in June 1946 observed the generalized appearance of multiple skin tumors which in the next three months increased rapidly in size and number. When he first came under our observation he was covered with hard tender skin nodules which varied in