Lymphocyte Response to Blood Transfusion in Man: a Comparison of Different Preparations of Blood

Abstract
The appearance of atypical lymphocytes in post-transfusion blood, their incorporation of 3H thymidine in tissue culture and the elimination of cytotoxic antibody production, were used as markers to show that frozen red cells are the least immunogenic when compared with dextran sedimented blood and whole blood donations. The absence of atypical lymphocytes and failure to produce lymphocytotoxic antibodies after transufsion of frozen cells is highly significant (P < 0.001) when compared with whole blood donations.