THE EXCRETION OF SPECIFIC FLUORESCENT SUBSTANCES IN THE URINE IN EXPERIMENTAL NICOTINIC ACID DEFICIENCY 12

Abstract
The fluorescent substances F1 and F2 occur in the urine of dogs with exptl. nicotinic acid deficiency. Observations on these animals are in agreement with those made in human pellagra, that acute nicotinic acid deficiency is characterized by the disappearance of F2 excretion and a rise in F1 excretion. As the disease becomes more chronic, the excretion of F1 likewise tends to fall. The effect of nieotinic acid in reversing these changes is illustrated.