Cyclic Biological Expression in Mouse Mammary Tumors
- 2 April 1982
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 216 (4541), 68-70
- https://doi.org/10.1126/science.7063874
Abstract
Biological characteristics were assessed in GR mouse mammary tumors during 22 serial transplantations. Although unidirectional progression from hormone dependency to independency was observed, other biological markers such as progesterone receptors, polyploid frequency and thymidine kinase activity demonstrated cyclic phenomena every fourth to sixth transplant generation, suggesting the continued presence of regulatory mechanisms among various cells subpopulations.This publication has 13 references indexed in Scilit:
- Relationship between proliferative activity and estrogen receptors in breast cancerCancer, 1979
- Clinical and pharmacological implications of cancer cell differentiation and heterogeneityBiochemical Pharmacology, 1979
- Estrogen Receptors and Responses to Chemotherapy and Hormonal Therapy in Advanced Breast CancerNew England Journal of Medicine, 1978
- The Clonal Evolution of Tumor Cell PopulationsScience, 1976
- Sex hormone receptors in mammary tumours of GR miceNature, 1976
- Thymidine kinase, DNA synthesis and cancerMolecular and Cellular Biochemistry, 1976
- Chromosome constitution of transitional cell carcinoma of the urinary bladderCancer, 1972
- The feedback inhibition of thymidine kinaseBiochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects, 1963
- FURTHER EVIDENCE FAVORING THE CONCEPT OF THE STEM CELL IN ASCITES TUMORS OF RATSAnnals of the New York Academy of Sciences, 1956