Ultrastructure of cutaneous cellular infiltrates in scleroderma
- 1 December 1977
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 113 (12), 1661-1666
- https://doi.org/10.1001/archderm.113.12.1661
Abstract
EM of the skin was performed in 10 patients with systemic and 4 with localized scleroderma. The following 3 groups of cells were identified: mature lymphocytes, T [thymus-derived] lymphoblasts, immature plasma cells and plasma cells; fibroblasts, fibrocytes and fibroblast-like cells; and macrophages, undifferentiated mesenchymal cells and monocytes. In those specimens with mononuclear cell infiltrates, the most common cells were lymphocytic-types, macrophages and fibroblasts with well-developed rough endoplasmic reticulum. In the specimens at the fibrotic stage, fibroblasts and histiocytic-type cells predominated. This study suggests that cellular and humoral immunity may play a role in the pathophysiology of scleroderma.This publication has 6 references indexed in Scilit:
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